It's not so much that she was disregarding his words, just the one they were coming from. A person was like a puzzle and sometimes all the pieces were there, sometimes a few went missing and sometimes half the picture could be hidden away in a place that was never meant to be found. This guy was still orbiting erratically around the later. First impressions were named such for a reason and one can't be taken back so easily.

"If they did," she replies in her own time, after appearing to give it some real thought. "We're all fucked." And she means it. She has her own reasons for thinking it unlikely but coming from the realm of possibility, she's being honest. They would target where there is still life left to live but she imagines genocide is a pretty effective tool against the gods too.

"So what do you plan to do about it?" she says, appealing to his profound concern.